The CRUZ is also compatible with car seats from several other brands. See all car seats compatible with the UPPAbaby CRUZ for a complete list of travel system options.
Simply place the car seat on the stroller frame and be sure each side is locked in.
The car seat also has a one handed release from the stroller, making it easy to attach and remove your car seat from the stroller. The MESA can be removed with just the touch of a button on the top of the handle.
See how the MESA and several other car seats attach to the CRUZ in the video below.